کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2963429 1178559 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease
چکیده انگلیسی

SummaryBackground and purposeMean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with coronary artery disease (CAD) in some studies. Insulin resistance contributes to increased platelet activation and it is one of the risk factors for CAD. The aim of this study was to assess the relationship between insulin resistance and MPV in non-obese, non-diabetic patients with CAD.Methods and subjectsSeventy-seven non-obese, non-diabetic CAD patients were divided into two groups, insulin resistant and insulin sensitive according to the homeostasis model assessment insulin resistance index (HOMA-IR). The insulin-resistant group was composed of 45 patients (30 males/15 females; mean age 59.8 ± 11.1 years). The insulin-sensitive group was composed of 32 patients (17 males/15 females; mean age 58.9 ± 12.2 years).ResultsInsulin and HOMA-IR values were significantly higher in insulin-resistant CAD patients than in insulin-sensitive CAD patients. The MPV values were significantly higher in insulin-resistant CAD patients than in insulin-sensitive CAD patients (8.6 ± 1.0 fl vs. 8.0 ± 0.7 fl; respectively, p = 0.01). The MPV was poorly correlated with HOMA-IR (r = 0.30, p = 0.054) and insulin (r = 0.22, p = 0.053).ConclusionsWe have shown that MPV was significantly elevated in insulin-resistant non-obese, non-diabetic CAD patients when compared to insulin-sensitive non-obese, non-diabetic CAD patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology - Volume 56, Issue 2, September 2010, Pages 154–158
نویسندگان
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