کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2964962 1178728 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coronary distensibility index measured by computed tomography is associated with the severity of coronary artery disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Coronary distensibility index measured by computed tomography is associated with the severity of coronary artery disease
چکیده انگلیسی

BackgroundAtherosclerotic changes within the coronary artery wall can affect vessel distensibility.ObjectiveThis study evaluated the relationship between the coronary distensibility index (CDI) and the severity of coronary artery disease (CAD) measured by computed tomographic angiography (CTA).MethodsOne hundred thirteen subjects, age 63 ± 10 years, 32% women, who underwent coronary artery calcium (CAC) scanning and CTA, were studied. Early diastolic and mid diastolic (MD) cross-section area (CSA) of the left anterior descending (LAD) artery were measured 5 mm distal to the left main bifurcation. CDI was defined as Δlumen CSA/[lumen CSA in MD × estimated central pulse pressure (eCPP)] × 103 {eCPP = 0.77 × peripheral pulse pressure}. LAD diameter measured by CTA and quantitative coronary angiography (QCA) was compared in 19 subjects without CAD. CAD was defined as normal (no stenosis and CAC 0), mild (stenosis ≤ 30%), moderate (stenosis 31%–69%), and severe (stenosis ≥ 70%) on CTA.ResultsExcellent correlation was observed between CTA and QCA measured by CDI (r2 = 0.96, P = 0.0001). CDI decreased from normal coronaries (6.75 ± 1.43) to arteries with mild (5.78 ± 1.45), moderate (3.96 ± 1.06), and severe (3.31 ± 1.06) disease (P = 0.004). The risk factor adjusted odds ratio of lowest versus 2 upper tertiles of CDI was 1.28 for mild, 8.47 for moderate, and 10.59 for severe CAD compared with the normal cohort. The area under the ROC curve to predict obstructive CAD (stenosis ≥ 50%) increased significantly from 0.71 to 0.84 by addition of CDI to CAC (P < 0.05).ConclusionCTA-measured CDI is inversely related to the severity of CAD independent of age, sex, cardiovascular risk factors, and CAC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiovascular Computed Tomography - Volume 4, Issue 2, March–April 2010, Pages 119–126
نویسندگان
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