کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2966210 | 1178797 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Impact of lipid profile and high blood pressure on endothelial damage Impact of lipid profile and high blood pressure on endothelial damage](/preview/png/2966210.png)
BackgroundEndothelial damage is an early component of atherosclerosis; however, the impact of cardiovascular risk factors on endothelial function is not clearly understood. We investigated the impact of lipid profiles and high blood pressure on damage.ObjectiveJapanese male outpatients with grade I or II hypertension, along with gender and age-matched normotensive subjects (both n = 25), were enrolled. Subjects with severe cardiovascular risk factors or illness or those taking medications were excluded. Blood was sampled for laboratory analysis and endothelial function was assessed by flow-mediated dilation (FMD).ResultsTotal cholesterol to high-density lipoprotein cholesterol ratio (total-C/HDL-C) was inversely correlated with the FMD value and positively correlated with both malondialdehyde-modified low-density lipoprotein and high-sensitivity C-reactive protein values. Stepwise regression analysis revealed total-C/HDL-C and systolic blood pressure were significant determinants of FMD. Hypertensive subjects had lower FMD values and similar lipid profiles to normotensive subjects. Grouping subjects according to total-C/HDL-C levels showed that those with high values had lower FMD values. Hypertensive subjects with low total-C/HDL-C had similar endothelial index values to those in normotensive subjects with high total-C/HDL-C. Logistic regression indicated hypertension and high total-C/HDL-C were significantly associated with low FMD values.ConclusionImpaired endothelial function was associated with increased total-C/HDL-C values, possibly as the result of increased vascular oxidative stress and inflammation. In the early stages of atherosclerosis, the impact of both total-C/HDL-C and BP may be similar in terms of endothelial damage.
Journal: Journal of Clinical Lipidology - Volume 5, Issue 6, November–December 2011, Pages 460–466