کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2998708 | 1180256 | 2013 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in Regenerative Orthopedics
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کلمات کلیدی
MSCDBMPDGFTGFPrPGDFGAMTricalcium phosphatePLAIVDFDAPCLcDNA - cDNAComplementary DNA - DNA تکمیلیiPS - IPSOsteoarthritis - استئوآرتریت(آرتروز)transforming growth factor - تبدیل فاکتور رشدIntervertebral disk - دیسک بین مهره ایFood and Drug Administration - سازمان غذا و داروinduced pluripotent stem - ساقه پلورپوفنت القا شده استMesenchymal stem cell - سلول های بنیادی مزانشیمیGrowth differentiation factor - عامل تمایز رشدplatelet-derived growth factor - فاکتور رشد حاصل از پلاکتTCP - قرارداد هدایت انتقالDemineralized bone matrix - ماتریکس استخوان دمینرالیزه شدهGene-activated matrix - ماتریکس فعال ژنBMP - مدیریت فرایند کسب و کارBone morphogenetic protein - پروتئین مورفوژنیک استخوانplatelet-rich plasma - پلاسمای غنی از پلاکت، PRP، پی آر پیPolylactic acid - پلی لاکتیک اسید یا اسید پلیلاکتیکPolycaprolactone - پلی کاپرولاکتونAutologous chondrocyte implantation - پیوند کاندروسیت اتولوگaci - چشم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Orthopedic injuries are common and a source of much misery and economic stress. Several relevant tissues, such as cartilage, meniscus, and intra-articular ligaments, do not heal. And even bone, which normally regenerates spontaneously, can fail to mend. The regeneration of orthopedic tissues requires 4 key components: cells, morphogenetic signals, scaffolds, and an appropriate mechanical environment. Although differentiated cells from the tissue in question can be used, most cellular research focuses on the use of mesenchymal stem cells. These can be retrieved from many different tissues, and one unresolved question is the degree to which the origin of the cells matters. Embryonic and induced pluripotent stem cells are also under investigation. Morphogenetic signals are most frequently supplied by individual recombinant growth factors or native mixtures provided by, for example, platelet-rich plasma; mesenchymal stem cells are also a rich source of trophic factors. Obstacles to the sustained delivery of individual growth factors can be addressed by gene transfer or smart scaffolds, but we still lack detailed, necessary information on which delivery profiles are needed. Scaffolds may be based on natural products, synthetic materials, or devitalized extracellular matrix. Strategies to combine these components to regenerate tissue can follow traditional tissue engineering practices, but these are costly, cumbersome, and not well suited to treating large numbers of individuals. More expeditious approaches make full use of intrinsic biological processes in vivo to avoid the need for ex vivo expansion of autologous cells and multiple procedures. Clinical translation remains a bottleneck.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 88, Issue 11, November 2013, Pages 1323-1339
Journal: Mayo Clinic Proceedings - Volume 88, Issue 11, November 2013, Pages 1323-1339
نویسندگان
Christopher H. PhD, DSc,