کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3000499 | 1180333 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in the Care of Patients With Intracerebral Hemorrhage
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کلمات کلیدی
PCCINRFFPrFVIIaemergency department - بخش اورژانسprothrombin complex concentrate - تمرکز پیچیده پروترومبینintracerebral hemorrhage - خونریزی داخل مغزیRecombinant activated factor VII - عامل فاکتور VII واکنش پذیرICH - منInternational Normalized Ratio - نسبت عادی بین المللیfresh-frozen plasma - پلاسما تازه منجمدSTICH - کوک
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Intracerebral hemorrhage (ICH), which comprises 15% to 30% of all strokes, has an estimated incidence of 37,000 cases per year. One third of patients are actively bleeding when they present to the emergency department, and hematoma growth during the first hours after ICH onset is thought to be a prime determinant of clinical deterioration. Inflammation, as opposed to ischemia, also negatively affects patient condition. Recombinant activated factor VII is emerging as a potential first-line therapy, especially in warfarin-associated hemorrhage. Corticosteroid therapy is not supported by contemporary studies or by current management guidelines. Aggressive blood pressure reduction is under investigation. Surgical intervention has shown no statistically significant benefit over medical management for patients with ICH in general, although subgroup analysis in a large randomized trial suggested potential benefits from surgery for patients with lobar ICH. Not long ago, ICH was considered virtually untreatable. Diligent efforts in both bench and clinical research are generating hope for patients who experience this catastrophic event.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 82, Issue 8, August 2007, Pages 987-990
Journal: Mayo Clinic Proceedings - Volume 82, Issue 8, August 2007, Pages 987-990
نویسندگان
Kristine M. MD, Sharon Y. MD, H. Keels S. MD, Jan M. MD, Thomas G. MD, Julia A. MD,