کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3000673 | 1180340 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Head and Neck Cancer: Changing Epidemiology, Diagnosis, and Treatment
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کلمات کلیدی
NPCHNSCCEORTCTPFAJCCFDGEGFR5-FURTOGSCCPFs - PF هاEBV - اپشتین بار ویروسprogression-free survival - بقا بدون پیشرفتoverall survival - بقای کلcomputed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایPositron emission tomography - توموگرافی گسیل پوزیترونEuropean Organization for Research and Treatment of Cancer - سازمان اروپایی تحقیقات و درمان سرطانWorld Health Organization - سازمان بهداشت جهانی5-fluorouracil - فلوروراسیل-۵، فلوئورواوراسیلEpstein-Barr virus - ویروس Epstein-BarrHuman papillomavirus - ویروس پاپیلوم انسانیHPV - ویروس پایپلوم انسانیPET - پتRadiation therapy - پرتودرمانی یا رادیوتراپیSquamous cell carcinoma - کارسینوم سلول سنگفرشیHead and neck squamous cell carcinoma - کارسینوم سلول سنگفرشی سر و گردنNasopharyngeal carcinoma - کارسینوم نازوفارنکسAmerican Joint Commission on Cancer - کمیسیون مشترک سرطان آمریکاWHO - کهRadiation Therapy Oncology Group - گروه رادیوتراپی OncologyEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Head and neck cancers account for less than 5% of all cancers and for less than 3% of all cancer deaths in the United States. The populations at risk for head and neck cancers are those who have a long-standing history of smoking and alcohol use. More recently, the incidence of oropharyngeal cancer in younger populations has been increasing and is associated with exposure to the human papillomavirus. This subset of patients appears to have a better overall prognosis and to respond better to treatment. This review is limited to head and neck cancers of squamous cell histology, which constitute more than 90% of head and neck cancers. Because treatment of head and neck cancers is complex and involves multiple modalities, a multidisciplinary approach is needed. This review focuses on the goal of organ preservation and postoperative treatment of high-risk patients with the concurrent use of chemotherapy and radiation therapy. This review also highlights recent advances in treatment using molecularly targeted therapies, specifically the role of inhibitors of the epidermal growth factor receptor in locally advanced and recurrent/metastatic squamous cell cancer of the head and neck. Studies in the English language were identified by searching the MEDLINE, EMBASE database (1980-2007) using the search terms head and neck, squamous cell, carcinoma, chemotherapy, radiation, human papillomavirus, epidermal growth factor receptor, and targeted therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 83, Issue 4, April 2008, Pages 489-501
Journal: Mayo Clinic Proceedings - Volume 83, Issue 4, April 2008, Pages 489-501
نویسندگان
Shanthi MD, Arlene A. MD,