کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3001740 1180668 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Renal haemodynamics and severity of carotid atherosclerosis in hypertensive patients with and without impaired renal function
ترجمه فارسی عنوان
همودینامیک کلیوی و شدت آترواسکلروز کاروتید در بیماران مبتلا به فشارخون با و بدون اختلال عملکرد کلیوی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• RRI is a marker of systemic vascular alterations in hypertensive patients.
• RRI is associated with severity of carotid atherosclerosis in the study subjects.
• This association is present in hypertensive patients with and without CKD.

Background and aimRenal resistance index (RRI), assessed by Duplex-Doppler sonography, has been classically considered as a mere expression of intrarenal vascular resistance. Recent studies, however, have showed that RRI is also influenced by upstream factors, especially arterial compliance, confirming its possible role as a marker of systemic vascular alterations.Several studies have shown that carotid intima-media thickness (cIMT) and carotid plaques (cP), assessed by ultrasonography, are documented markers of subclinical organ damage as well as expression of progressive atherosclerotic disease, and that they get worse with the progressive deterioration of renal function.The study was aimed to evaluate the relationship between RRI and severity of carotid atherosclerosis in hypertensive subjects with and without impaired renal function.Methods and resultsThe study population, including 263 hypertensive patients (30–70 years), was split into 3 groups based on cIMT and presence of cP (cIMT ≤ 0.9 mm and no cP; cIMT > 0.9 mm and no cP; cP). All patients were also divided into 2 subgroups (normal renal function; CKD stage I–IV).A stepwise increase in RRI corresponding to the groups of progressive severity of carotid atherosclerosis was observed (respectively 0.61 ± 0.07, 0.65 ± 0.06, 0.68 ± 0.06; p < 0.001). A strong positive correlation was observed between RRI and cIMT in the whole population (r = 0.43; p < 0.001) and in the subgroups with (r = 0.42; p < 0.001) and without (r = 0.39; p < 0.001) CKD. These associations remained statistically significant even after adjustment for various confounding factors.ConclusionShowing a close association between RRI and severity of carotid atherosclerosis, our results strengthen the concept that RRI is a marker of systemic vascular changes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 25, Issue 2, February 2015, Pages 160–166
نویسندگان
, , , , , , ,