کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3001757 1180669 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum uric acid level and left ventricular hypertrophy in elderly male patients with nonvalvular atrial fibrillation
ترجمه فارسی عنوان
سطح سرمی اسید اوریک و هیپرتروفی بطن چپ در بیماران مرد سالم با فیبریلاسیون دهلیزی غیر واگیردار
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• The relationship between SUA and LVH was firstly demonstrated in non-valvular atrial fibrillation patients.
• SUA was independently associated with LVH in older male patients with non-valvular atrial fibrillation.
• Hyperuricemia patients showed poorer renal function, heart function, and metabolic profiles than the normal group.

Background and aimsRecent studies have suggested that serum uric acid (SUA) induces oxidative stress and inflammation, which are involved in the mechanism of cardiac hypertrophy. In patients with atrial fibrillation (AF), comorbidity of left ventricular hypertrophy (LVH) exacerbates cardiac function. In this study, we investigated the association between SUA and cardiac hypertrophy in AF patients.Methods and resultsInitially, 1296 consecutive elderly patients (age >60) with nonvalvular AF were retrospectively selected from the inpatient clinic between January 2012 and April 2015. Demographic, clinical, and echocardiographic characteristics were carefully recorded. The final study population was 577 patients. The mean SUA level was significantly higher in patients with LVH than those without LVH. Compared with the non-LVH group, the LVH group was older, had a higher percentage of female patients, and had lower hemoglobin levels and estimated glomerular filtration rates. Patients in the LVH group also had a higher rate of coronary heart disease and fewer had history of radiofrequency ablation compared with the non-LVH group. In the hyperuricemia group, B-type natriuretic peptide levels, left atrial diameter, left ventricular mass index, and percentage of NYHA (New York Heart Association) class III/IV were significantly higher than the SUA normal group. Multivariate logistic regression analysis indicated the independent risk factors for LVH in elderly AF patients included SUA, age, male sex, the presence of coronary heart disease, and diuretic therapy. Subgroup analysis identified SUA as a significant risk factor associated with LVH in men.ConclusionsSUA was independently associated with LVH in elderly male patients with nonvalvular AF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 26, Issue 7, July 2016, Pages 575–580
نویسندگان
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