کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3002077 1180698 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flavonoids and arterial stiffness: Promising perspectives
ترجمه فارسی عنوان
فلاونوئیدها و سفتی شریان: چشم اندازهای چشمگیری
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Background and aimsFlavonoids are a group of polyphenol compounds, ubiquitously found in plants. Great emphasis has been given to their possible benefits for cardiovascular health. These beneficial effects may be mediated by a specific action on arterial walls. Arterial stiffness is a marker of vascular aging, increasingly used in the clinical setting and assessed by pulse wave velocity. It has shown to be a robust predictor of cardiovascular events and mortality. This review aims at providing a comprehensive evaluation of available intervention and observational studies examining the relationship between flavonoid consumption and arterial stiffness.Data synthesisA Medline® literature search was performed using the keywords “arterial stiffness” and “flavonoids”. As a result, 2 cross-sectional and 16 intervention studies assessing the relationship between flavonoids intake and arterial stiffness were retained. Four intervention trials reported a significant decrease of arterial stiffness after a flavonoid-based intervention, independently from blood pressure changes. The two observational studies reported significant associations between a higher flavonoid consumption and a lower arterial stiffness. In this review, isoflavones, anthocyanins and to a lesser extent cocoa flavan-3-ols appeared to be the more efficient to improve vascular function.ConclusionsDespite their heterogeneity, preliminary data seem to support an improvement of the arterial stiffness related to flavonoid intake. However, further research on absorption and dose–response effects of the specific flavonoid subclasses on arterial structure is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 24, Issue 7, July 2014, Pages 698–704
نویسندگان
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