کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3002224 | 1180709 | 2012 | 10 صفحه PDF | دانلود رایگان |
Background and aimTo assess cardiovascular risk distribution, distribution of individual low-density lipoprotein (LDL)-cholesterol target and distance of LDL cholesterol from the target in a representative sample of the Italian population.Methods and resultsCross-sectional, population-based study of a representative sample of the Italian adult population, comprising 5458 individuals (from 40 to 79 years of age, both sexes) from general practices in Italy.Of the subjects, 65.2% were in the low-cardiovascular-risk class, whereas 10.5%, 18.3% and 6.0% had moderate, high, and very high cardiovascular risk profiles, respectively; 8.2% of the subjects were treated with statins at enrolment. Of the cohort, 68.3% displayed LDL-cholesterol values below their LDL target, as calculated according to their individual risk profile. Among the 31.7% ‘not at target’, 42.3% were ≤15%, 44.3% were between 15% and 40% and 13.4% were >40% over their LDL target.ConclusionsAbout two-thirds of adults in a low-cardiovascular-risk country, such as Italy, have LDL-cholesterol levels ‘at target’, as defined in current guidelines. Accordingly, the remaining subjects require a lifestyle or pharmacological intervention to reach their target; 24% of the total cohort, in detail, need to be treated with a statin (or to continue the prescribed statin treatment) to reach the proper LDL target. This type of data analysis might help to optimise resource allocation in preventive medicine.
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 22, Issue 4, April 2012, Pages 327–336