کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3002904 1180755 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute effects of 5-methyltetrahydrofolate on endothelial function and asymmetric dimethylarginine in patients with chronic heart failure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Acute effects of 5-methyltetrahydrofolate on endothelial function and asymmetric dimethylarginine in patients with chronic heart failure
چکیده انگلیسی

SummaryBackground and aimsFolic acid enhances endothelial function in vascular disease states but its effects in chronic heart failure (CHF) are largely unknown. We studied the acute effects of i.v. methyltetrahydrofolate (5MTHF), the active metabolite of folic acid, on endothelial function and asymmetric dimethylarginine (ADMA) in CHF patients.Methods and resultsTwenty two CHF patients and 22 controls received one of the following three-step infusions (1 h per each step) in a randomized, parallel group, placebo-control study: (1) active treatment (saline, 5MTHF, and 5MTHF + the endothelial nitric oxide inhibitor NG-monomethyl l-arginine, LNMMA); or (2) placebo (saline × 3). Endothelium-dependent vasodilatation was assessed by pulse-wave analysis (salbutamol-mediated changes in augmentation index, AIx). 5MTHF did not exert any significant effects on endothelium-dependent vasodilatation both in controls [ΔAIx post-salbutamol baseline −7.6% (−24.8/−4.1) vs. 5MTHF −5.5% (−16.7/−3.6), medians and interquartile range, and CHF patients [−1.8% (−17.3/+1.3) vs. −2.4% (−3.8/−1.2)]. However, a significant reduction in ADMA concentrations was observed in both groups [controls baseline 0.68 μmol/L (0.64/0.77) vs. 5MTHF 0.65 (0.57/0.74); CHF baseline 0.76 (0.63/0.82) vs. 5MTHF 0.69 (0.66/0.71), P = 0.05 for both vs. baseline and placebo. These effects persisted during co-infusion with LNMMA.Conclusion5MTHF did not affect endothelial function but significantly reduced serum ADMA concentrations both in CHF patients and controls. This suggests a direct effect of 5MTHF on ADMA metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 20, Issue 5, June 2010, Pages 341–349
نویسندگان
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