کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3003139 1180767 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using brachial-ankle pulse wave velocity to associate arterial stiffness with cardiovascular risks
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Using brachial-ankle pulse wave velocity to associate arterial stiffness with cardiovascular risks
چکیده انگلیسی

Background and aimsThis study aimed to elucidate the relationship between brachial-ankle pulse wave velocity (baPWV) and conventional cardiovascular risk factors.Methods and resultsA total of 192 subjects with low to intermediate risk was enrolled in a cardiovascular evaluation program. A multiple regression model was built to find significant cardiovascular biomarkers for predicting baPWV. A logistic regression model was developed to associate baPWV and other biomarkers with the risk of cardiac diastolic dysfunction. A total of 123 men (mean age: 52.6 ± 12.0) and 69 women (mean age: 51.7 ± 10.4) was included. Age, blood pressure, C-reactive protein, serum homocysteine, heart rate, and blood urea nitrogen were positively predictive of increased pulse wave velocity. In turn, baPWV increased the risk (odds ratio: 1.257 for each m/s, 95% CI: 1.105 ∼ 1.430, p < 0.001) and high-density lipoprotein decreased the risk for cardiac diastolic dysfunction (0.962 for each mg/dl, 95% CI: 0.925 ∼ 1.000, p = 0.05). The correlation between baPWV and Framingham 10-year risk was moderate (men: r = 0.306, p = 0.002; women r = 0.548, p < 0.001).ConclusionThe results suggest that baPWV is a composite risk factor for early atherosclerotic change and a predictor for the development of diastolic dysfunction and long-term cardiovascular risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 19, Issue 4, May 2009, Pages 241–246
نویسندگان
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