کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3014001 | 1181874 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adenosina induce arritmias ventriculares en corazones con miocardiopatÃa chagásica crónica
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adenosina induce arritmias ventriculares en corazones con miocardiopatÃa chagásica crónica Adenosina induce arritmias ventriculares en corazones con miocardiopatÃa chagásica crónica](/preview/png/3014001.png)
چکیده انگلیسی
Adenosine released during ischemia and hypoxia can induce ventricular arrhythmias. This phenomenon is also observed in Chagas disease. This study involved pharmacologic analysis of the arrhythmogenic properties of adenosine in healthy Sprague-Dawley rats (n=14) and in rats with chronic Chagas cardiomyopathy (n=14). Electrocardiographic and pharmacologic studies were performed on isolated hearts prepared using the Langendorff method. Adenosine increased ventricular arrhythmias in both groups of animals in a dose-dependent manner: 50% of chagasic rats developed ventricular fibrillation compared with 7.14% of healthy rats (P<.05). Fibrillation was prevented by A1 (i.e., DPCPX) and A2a (i.e., 8-CSC) receptor antagonists. Arrhythmia was associated with a prolonged QT interval, early depolarization, and the R-on-T and torsade de pointes phenomena. In conclusion, adenosine is a proarrythmic drug that is able to induce ventricular fibrillation in chagasic rat hearts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Española de CardiologÃa - Volume 63, Issue 4, April 2010, Pages 478-482
Journal: Revista Española de CardiologÃa - Volume 63, Issue 4, April 2010, Pages 478-482
نویسندگان
Edilmar Alvarado-Tapias, Marianna Rivas-Coppola, Alfonso Alvarado, MarÃa Bello, Mario Briceño, Claudina RodrÃguez-Bonfante, Rafael Bonfante-Cabarcas,