Association between the prothrombin G20210A mutation and sudden sensorineural hearing loss in European population: A meta-analysis

PurposeEpidemiological studies have reported inconsistent findings on the association between the prothrombin G20210A mutation and sudden sensorineural hearing loss (SSNHL) in European population. The aim of this meta-analysis was to clarify the association of this polymorphism with SSNHL in European population.MethodsPubMed, Embase, and the China National Knowledge Infrastructure (CNKI) were searched up to August 1, 2014. We used STATA12.0 to calculate summary odds ratios (ORs) with 95% confidence intervals (CIs).ResultsEight studies including 1972 patients were identified. Pooled data showed no significant association between the prothrombin G20210A mutation and risk of SSNHL in European population : A vs. G (OR = 1.645, 95% CI:0.78-3.49,POR = 0.194); AG vs.GG (OR = 1.660, 95% CI:0.77-3.60,POR = 0.199).ConclusionsThe present meta-analysis suggests that the prothrombin G20210A mutation is not significantly associated with an increased risk of SSNHL in European population.