ATP-binding cassette transporter 1 C69T and V825I polymorphisms in the development of atherosclerosis: A meta-analysis of 18,320 subjects

• We performed a meta-analysis to derive a more precise estimation of the relationship
• Our study has the potential to detect small effects in genetic association studies
• Our study suggests that ABCA1 C69T polymorphism is associated with AS risk

IntroductionATP-binding cassette transporter 1 (ABCA1), a member of the ATP-binding cassette family, plays a critical role in the development of atherosclerosis (AS). This meta-analysis was performed to assess the associations of ABCA1 C69T and V825I polymorphisms with AS susceptibility.Materials and methodsA comprehensive search was conducted to identify all eligible studies from PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar. Additionally, hand searching of the references of identified articles was performed. All statistical analyses were done with Review Manager 5.1.4 and Stata 11.0.ResultsEleven articles involving 14 studies were included in the final meta-analysis. For the ABCA1 C69T polymorphism, six studies involving 1854 AS cases and 5744 controls were combined showing significant association between this variant and AS risk (for T allele vs. C allele: OR = 1.44, 95% CI = 1.04-1.24, p = 0.005; for T/T vs. C/C: OR = 1.39, 95% CI = 1.12-1.73, p = 0.003; for T/T vs. C/T + C/C: OR = 1.34, 95% CI = 1.09-1.65, p = 0.006; for T/T + C/T vs. C/C: OR = 1.13, 95% CI = 1.01-1.27, p = 0.040). For the ABCA1 V825I polymorphism, eight studies involving 2026 AS cases and 8696 controls were combined. There was no significant association between the variant and AS risk (for I allele vs. V allele: OR = 1.18, 95% CI = 0.90-1.53, p = 0.230; for I/I vs. V/V: OR = 1.29, 95% CI = 0.75-2.23, p = 0.360; for I/I vs. V/I + V/V: OR = 1.40, 95% CI = 0.87-2.26, p = 0.160; for I/I + V/I vs. V/V: OR = 1.15, 95% CI = 1.00-1.33, p = 0.060).ConclusionsThis meta-analysis suggested that the ABCA1 C69T polymorphism was associated with an increased AS risk. Furthermore, there was no significant association between the ABCA1 V825I polymorphism and AS risk.