کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3029401 1183070 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of tissue factor procoagulant activity by post-translational modifications
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Regulation of tissue factor procoagulant activity by post-translational modifications
چکیده انگلیسی

Post-translational modification of amino acid residues is a common way to regulate localization, stability and ultimately the function of the protein. Tissue factor (TF), the major initiator of blood coagulation cascade, receives several post-translational modifications, like glycosylation, phosphorylation, palmitoylation and nitrosylation. Recent studies have demonstrated that these processes play important roles in modulating biological functions of TF. The present review highlights the mechanisms of several common protein post-translational modifications of TF with the special reference on the recent knowledge about their roles in regulation of trafficking, stability as well as procoagulant and signaling functions of TF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 122, Issue 6, 2008, Pages 831–837
نویسندگان
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