Evaluation of a new silica clotting time in the diagnosis of lupus anticoagulants

In comparison with PTT-LA as screening test, the SCT screen shows an acceptable sensitivity. However, the HemosIL™ SCT assay including the confirmation step, has a much lower sensitivity in the diagnosis of LAC in comparison with the Staclot-LA test. Combining the HemosIL™ SCT assay with dRVVT results in a better sensitivity, although lower than the combined aPTT/dRVVT based method as usually performed in our lab.