کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3030092 1183159 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
INR comparison between the CoaguChek® S and a standard laboratory method among patients with self-management of oral anticoagulation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
INR comparison between the CoaguChek® S and a standard laboratory method among patients with self-management of oral anticoagulation
چکیده انگلیسی

IntroductionPortable coagulation monitors have been developed to measure International Normalised Ratio (INR) in orally anticoagulated patients using capillary whole blood from a finger stick. Because of unsatisfactory precision of some of the monitors in comparison with laboratory methods new devices are being developed. In the present study we compared INR determination with the CoaguChek S device with a standard laboratory method among patients with self-management of oral anticoagulation (OAC).MethodsTwo hundred and forty-two patients performing self-management of OAC were enrolled into this study. Parallel INR measurements were performed within one hour. Capillary INR measurements (INRcap) were done by the patients with the CoaguChek S and venous INR (INRven) by qualified medical staff using a standard laboratory method.ResultsWe found a correlation coefficient (rS) of 0.85 (95% CI: 0.81–0.88) among the 242 patients between INRven and INRcap. In 84.4% of the INR parallel measurements the difference between the two values was below 0.5 INR units. In only 2 of 242 cases the difference was > 1 INR unit (1.1 and 1.3). The slope of the Passing Bablok regression line was 0.91 (95% CI: 0.83–1.0) and the y-intercept 0.06 (95% CI: − 0.20–0.25). Agreement between both methods was 90.5% (95% CI: 86.8–94.2) and standard-agreement even 97.1% (95% CI: 95–99.2).ConclusionsINR measurement with CoaguChek S device by trained patients revealed reliable results in comparison to the values obtained with a standard laboratory method.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 119, Issue 4, 2007, Pages 489–495
نویسندگان
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