کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3030411 1183206 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnosis and treatment of heparin-induced thrombocytopenia in neonates and children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Diagnosis and treatment of heparin-induced thrombocytopenia in neonates and children
چکیده انگلیسی

Heparin-induced thrombocytopenia (HIT), a well-known side effect of heparin therapy, occurs with an incidence of 1–2% in certain pediatric patient groups. In affected children, HIT markedly increases the risk of venous and arterial thromboembolism. The use of alternative anticoagulation with danaparoid, lepirudin and argatroban in adults and children has demonstrated to be safe and could reduce morbidity and mortality also in affected pediatric patients. Thus, in children and neonates, an early diagnosis and accurate management is crucial to avoid the deleterious consequences of HIT. This review article will focus on the presentation of HIT in neonates and children. It reviews the pathophysiology of HIT and it summarizes epidemiological data. Finally important diagnostic and therapeutic issues are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 118, Issue 1, 2006, Pages 123–135
نویسندگان
, , ,