کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3031986 1183991 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebrospinal fluid biomarkers in Alzheimer's disease: Diagnostic accuracy and prediction of dementia
ترجمه فارسی عنوان
بیومارکرهای مایع مغزی نخاعی در بیماری آلزایمر: دقت تشخیصی و پیش بینی زوال عقل
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

IntroductionGuidelines for the use of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) establish that each laboratory must use internally qualified cutoff values. We determined the concentrations of biomarkers that discriminate cases from controls and combinations that predict the progression to dementia in a Brazilian cohort.MethodsConcentrations of amyloid-beta peptide (Aβ1–42), total tau (T-tau), and 181Thr-phosphorylated-tau (P-tau) were determined in CSF samples from 184 older adults (68 mild cognitive impairment, 41 AD, 34 non-AD cognitive impairment, and 41 controls) by the INNO-BIA AlzBio3 assay.ResultsCutoff values discriminating AD from controls are as follows: Aβ1–42: 416.0 pg/mL (sensitivity [SE]: 83%, specificity (SP): 70%); T-tau: 76.7 pg/mL (SE: 82%, SP: 67%); P-tau: 36.1 pg/mL (SE: 83%, SP: 49%); Aβ1–42/P-tau <9.53 (SE: 88%, SP: 78%); and Aβ1–42/T-tau <4.13 (SE: 80%; SP: 80%). Combining values Aβ1–42 <416.5 pg/mL and Aβ1–42/P-tau <9.5 best predicted the conversion in 2 years (Cox regression: hazard ratio 7.24 [2.09–25.06], P = .002, SE: 74%, Sp: 73%).DiscussionOur findings are in line with most of the available evidence in this field; yet, our cutoff values are different from those derived from other laboratories.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - Volume 1, Issue 4, December 2015, Pages 455–463
نویسندگان
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