کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3035568 | 1579575 | 2007 | 5 صفحه PDF | دانلود رایگان |

Vagal afferent neurons from the stomach may be activated not only by chemical stimuli in the mucosa but also by circulating factors. In the present study, we have used electrophysiological techniques to characterize functional activity of several receptors for chemical mediators on unmyelinated axons in isolated fascicles of human gastric vagus nerve. Application of agonists at the nicotinic acetylcholine receptor (nAChR), 5-HT3 subtype of serotonin receptor, and the transient receptor potential vanilloid receptor-1 (TRPV1) resulted in a change in the height and/or threshold of the C-fiber compound action potential. These effects were blocked by specific antagonists of nAChR (mecamylamine), 5-HT3 (Y-25130), and TRPV1 (capsazepine). We conclude that the chemosensitivity of unmyelinated vagal axons can be studied using isolated segments of human gastric vagus nerve. The presence of receptors indicates that circulating factors may modify vagal afferent neurons also by effects on the axonal membrane.
Journal: Autonomic Neuroscience - Volume 136, Issues 1–2, 30 October 2007, Pages 100–104