Subacute sclerosing panencephalitis (SSPE) the story of a vanishing disease

Subacute sclerosing panencephalitis (SSPE), is a devastating “slow virus” brain disease which affects young children who had measles some 6–7 years earlier.Although, the pandemic of SSPE during 1960–1980’s was almost eradicated due to mass immunization, the disease is still taking the life of young children in countries where measles immunization is incomplete and in world regions where genetic polymorphism to this particular infection is present. The present review was written for the fortunate young generation of pediatricians and pediatric neurologists who probably have not seen a case of SSPE during their career, and for those who work in counties where the disease has not been eradicated. It is also a reminder that with full coverage of measles immunization this devastating disease can be fully eradicated.