کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3043672 1184983 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the estimation of silent period thresholds in transcranial magnetic stimulation
ترجمه فارسی عنوان
برآورد آستانه دوره سکوت در تحریک مغناطیسی ترانس مغناطیسی
کلمات کلیدی
تحریک مغناطیسی ترانس مغناطیسی، حملات نورونی، قشر مکرر، منحنی آستانه، الکترومیوگرافی، دوره خاموش
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• We evaluated novel individual thresholds in measurements of corticospinal silent periods (SPs) to assess the subject-specific inhibition with transcranial magnetic stimulation.
• The use of the measured SP-thresholds decreased the inter-individual variation in SP durations when compared with those induced in relation to the individual resting motor threshold.
• By using individual SP-thresholds the assessment of corticospinal inhibition may be improved and the effects of excitatory components have less influence on the measurements.

ObjectiveWe evaluated the induction of corticospinal silent period (SP) using transcranial magnetic stimulation (TMS) at stimulation intensities normalized to resting motor threshold (rMT) or silent period thresholds (SPTs). The aim was to reduce the characteristic inter-individual variation in SP measurements in healthy population to improve the sensitivity of such measurements.MethodsThe cortical representation area of the right hand musculature of 12 healthy subjects was stimulated with navigated TMS with varying stimulating intensities. Subsequently, the individual SPTs for eliciting SPs of 20, 30, and 50 ms in duration were determined from the input–output characteristics.ResultsWhile SPT for 20 and 50 ms SPs differed from rMT, the SPT for 30 ms was similar to rMT. Nevertheless, the inter-individual variation in SP duration was reduced significantly at 120% of SPT30 when compared with SP durations obtained at 120% of rMT.ConclusionsInter-individual variation in the SP duration decreases when applying TMS at stimulation intensities normalized to the individual SPTs instead to the rMT. This makes the SP duration more specific to inhibition and less affected by changes in cortical excitability.SignificanceUse of individual SPTs may improve the sensitivity of the SP measures in studies with inter-individual design.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 125, Issue 11, November 2014, Pages 2247–2252
نویسندگان
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