کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3054179 1580045 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic impact of topiramate on acid-base balance and potassium in childhood
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Chronic impact of topiramate on acid-base balance and potassium in childhood
چکیده انگلیسی

Topiramate, which is commonly prescribed for seizure disorders and migraine prophylaxis, sometimes causes metabolic acidosis and hypokalemia. Since the effects of topiramate on acid–base balance and potassium levels have not been well explored in children, acid–base balance, anion gap and potassium were assessed in 24 patients (8 females and 16 males) aged between 4.6 and 19 years on topiramate for more than 12 months and in an age-matched control group. Plasma bicarbonate (21.7 versus 23.4 mmol/L; P < 0.03), carbon dioxide pressure (39.7 versus 43.2 mm Hg; P < 0.05), and potassium (3.7 versus 4.0 mmol/L; P < 0.03) were on the average lower and chloride (109 versus 107 mmol/L; P < 0.03) higher in patients treated with topiramate than in controls. Blood pH, plasma sodium and the anion gap were similar in patients on topiramate and in controls. In patients on topiramate no significant correlation was observed between the dosage of this agent and plasma bicarbonate or potassium as well as between topiramate blood level and the mentioned electrolytes. In conclusion long-term topiramate treatment is associated with a mild, statistically significant tendency towards compensated normal anion gap metabolic acidosis and hypokalemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 14, Issue 5, September 2010, Pages 445–448
نویسندگان
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