کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3062371 | 1187489 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Relationship of neural stem cells with their vascular niche: Implications in the malignant progression of gliomas Relationship of neural stem cells with their vascular niche: Implications in the malignant progression of gliomas](/preview/png/3062371.png)
During embryogenesis and in regions of the adult brain undergoing post-natal neurogenesis, neural stem cells and endothelial precursors are found within a vascular niche, where the coordinated interactions between neurogenesis and vasculogenesis dictates development and responses to the environment. Moreover, recent evidence suggests that gliomas may arise from transformed neural stem cells and that angiogenesis is important in the malignant progression of these tumors. Taken together, these findings have led researchers to focus on the dynamic interaction between neural stem cells and their vascular niche so as to find new therapeutic strategies to halt the progression of gliomas. This review summarizes the cellular substrates responsible for the coordinated interactions between the nervous and vascular systems and how this relates to gliomagenesis.
Journal: Journal of Clinical Neuroscience - Volume 15, Issue 11, November 2008, Pages 1193–1197