کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3063054 | 1187505 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice](/preview/png/3063054.png)
Astrocytes perform a variety of functions in the adult central nervous system. Recent evidence suggests that the upregulation of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament component, is a biological marker of neurotoxicity after cerebral injury. We herein compared the response to traumatic brain injury or kainic acid (KA)-induced neurotoxicity in GFAP knockout (GFAP-KO) and wild-type (WT) mice. Seventy-two hours after injury, all GFAP-KO mice showed hippocampal CA3 neurodegeneration, whereas WT mice did not show neurodegeneration. Seventy-two hours after KA administration, GFAP-KO mice were more susceptible to KA-induced seizures and had an increased number of pyknotic damaged CA3 neurons than did WT mice. These results indicate that GFAP plays a crucial role in pyramidal neuronal survival after injury or KA-induced neurotoxicity.
Journal: Journal of Clinical Neuroscience - Volume 13, Issue 9, November 2006, Pages 934–938