کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3063843 1580381 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis
چکیده انگلیسی


• E2 treatment induces B cell regulation by IL-10 and IFN-γ dependent pathways in EAE.
• E2 treatment enhances the frequency of regulatory B cells in the CNS.
• E2 treatment enhances the frequency of M2 microglia in the CNS.

Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-γ dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection.

Figure optionsDownload high-quality image (69 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 293, 15 April 2016, Pages 45–53
نویسندگان
, , , , , , , , ,