کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064210 1580408 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders
چکیده انگلیسی


• CSF NFL was the only one of 7 brain cell-specific markers elevated in untreated OMS.
• During multimodal immunotherapy, the concentration dropped to control concentrations.
• Astroglial markers were normal and unchanged by the same immunotherapies.
• This is the first biochemical evidence of neuronal/axonal injury in some OMS.
• Other pediatric neuroimmunological disorders had the highest CSF NFL concentrations.

Using a panel of seven brain cell-specific biomarkers in cerebrospinal fluid (CSF), pediatric opsoclonus–myoclonus syndrome (OMS) (n = 234) was compared to pediatric non-inflammatory neurological controls (n = 84) and other inflammatory neurological disorders (OIND) (n = 44). Only CSF NFL was elevated in untreated OMS versus controls (+ 83%). It was 87% higher in OIND than in OMS. On combination treatment with front-loaded ACTH, IVIg, rituximab, median CSF NFL decreased by 60% to control levels. These biochemical data suggest neuronal/axonal injury in some children with OMS without indicators of astrogliosis, and reduction on sufficient immunotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 266, Issues 1–2, 15 January 2014, Pages 75–81
نویسندگان
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