کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064228 | 1580411 | 2013 | 12 صفحه PDF | دانلود رایگان |

• IL-21 optimizes CNS CD4 and CD8 T cell responses during viral encephalomyelitis.
• IL-21 promotes peripheral and CNS humoral immunity.
• IL-21 promotes CNS viral control and prevents mortality.
Acute coronavirus encephalomyelitis is controlled by T cells while humoral responses suppress virus persistence. This study defines the contribution of interleukin (IL)-21, a regulator of T and B cell function, to central nervous system (CNS) immunity. IL-21 receptor deficiency did not affect peripheral T cell activation or trafficking, but dampened granzyme B, gamma interferon and IL-10 expression by CNS T cells and reduced serum and intrathecal humoral responses. Viral control was already lost prior to humoral CNS responses, but demyelination remained comparable. These data demonstrate a critical role of IL-21 in regulating CNS immunity, sustaining viral persistence and preventing mortality.
Journal: Journal of Neuroimmunology - Volume 263, Issues 1–2, 15 October 2013, Pages 43–54