کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064418 1580438 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
چکیده انگلیسی

An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4+ T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-γ+ CD4+ T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 235, Issues 1–2, June 2011, Pages 91–97
نویسندگان
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