کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064602 | 1580452 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception](/preview/png/3064602.png)
چکیده انگلیسی
In the present study, intraperitoneal administration of minocycline attenuated enhancing nociceptive behaviors in those rats receiving dual formalin injections (5% formalin followed at 7 days later by 1% formalin). The minocycline treatment did not prevent the increase in OX-42 and MHC class I labeling and morphological changes, but significantly attenuated upregulation of phospho-p38 in activated microglia. These results suggest that the later days of microglial activation with upregulated immune markers in the spinal cord contributes to enhancing long-term pain response by a pathway of p38 activation in microglia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 221, Issues 1–2, 15 April 2010, Pages 25–31
Journal: Journal of Neuroimmunology - Volume 221, Issues 1–2, 15 April 2010, Pages 25–31
نویسندگان
Kai Li, Kai-Yuan Fu, Alan R. Light, Jianren Mao,