کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064612 | 1580452 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 221, Issues 1–2, 15 April 2010, Pages 95–100
Journal: Journal of Neuroimmunology - Volume 221, Issues 1–2, 15 April 2010, Pages 95–100
نویسندگان
Makoto Hirotani, Masaaki Niino, Toshiyuki Fukazawa, Seiji Kikuchi, Ichiro Yabe, Shinsuke Hamada, Yasutaka Tajima, Hidenao Sasaki,