کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064627 1580449 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The emerging role for chemokines in epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The emerging role for chemokines in epilepsy
چکیده انگلیسی

Epilepsy has been considered mainly a neuronal disease, without much attention to non-neuronal cells. In recent years growing evidence suggest that astrocytes, microglia, blood leukocytes and blood–brain barrier breakdown are involved in the pathogenesis of epilepsy. In particular, leukocyte–endothelium interactions and eventually subsequent leukocyte recruitment in the brain parenchyma seem to represent key players in the epileptogenic cascade. Chemokines are chemotactic factors controlling leukocyte migration under physiological and pathological conditions. In the light of recent advances in our understanding of the role of inflammation mechanisms in the pathogenesis of epilepsy, pro-inflammatory chemokines may play a critical role in epileptogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 224, Issues 1–2, 27 July 2010, Pages 22–27
نویسندگان
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