کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064659 | 1580447 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The common neurotrophin receptor P75NTR, its co-receptor sortilin and ligand proNGF, have not previously been investigated in Natural Killer (NK) cell function. We found freshly isolated NK cells express sortilin but not significant amounts of P75NTR unless exposed to interleukin-12 (IL-12), or cultured in serum free conditions, suggesting this receptor is sequestered. A second messenger associated with p75NTR, neurotrophin-receptor-interacting-MAGE-homologue (NRAGE) was identified in NK cells. Cleavage resistant proNGF123 killed NK cells in the presence of IL-12 after 20Â h and without IL-12 in serum free conditions at 48Â h. This was reduced by blocking sortilin with neurotensin. We conclude that proNGF induced apoptosis of NK cells may have important implications for limiting the innate immune response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 226, Issues 1â2, 14 September 2010, Pages 93-103
Journal: Journal of Neuroimmunology - Volume 226, Issues 1â2, 14 September 2010, Pages 93-103
نویسندگان
Mary-Louise Rogers, Sheree Bailey, Dusan Matusica, Ian Nicholson, Hakan Muyderman, Promila C. Pagadala, Kenneth E. Neet, Heddy Zola, Peter Macardle, Robert A. Rush,