کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064680 1580453 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing?
چکیده انگلیسی

Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to quell virus replication, drive the pathogen into a “latent” state, and likely hinder viral reactivation, collateral damage can ensue with demonstrable cell death and foci of tissue pathology in the central nervous system (CNS) as a result of the release of inflammatory mediators including reactive oxygen species. Although rare, HSV-1 is the leading cause of frank sporadic encephalitis that, if left untreated, can result in death. A greater understanding of the contribution of resident glial cells and infiltrating leukocytes within the CNS in response to HSV-1 invasion is necessary to identify candidate molecules as targets for therapeutic intervention to reduce unwarranted inflammation coinciding with the maintenance of the anti-viral state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 220, Issues 1–2, 30 March 2010, Pages 1–9
نویسندگان
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