کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064803 | 1580463 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The complement factor C5a receptor is upregulated in NFL−/− mouse motor neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The complement factor C5a receptor is upregulated in NFL−/− mouse motor neurons The complement factor C5a receptor is upregulated in NFL−/− mouse motor neurons](/preview/png/3064803.png)
چکیده انگلیسی
In NFL−/− mice, a model of motor neuron degeneration in ALS, degenerating spinal motor neurons express high levels of the receptor for the C5a anaphylatoxin (C5aR) early in the disease process. C5a is a potent in vitro neurotoxin for both Neuro2A and NGF-differentiated PC12 cells. While no interaction was observed between glutamate and C5a, both C5a and kainate upregulated the expression of activated C5aR. C5aR expression was increased in motor neurons in ALS. This data suggests that the early upregulation of C5aR may contribute to motor neuron damage that potentiates excitotoxicity in ALS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 210, Issues 1–2, 29 May 2009, Pages 52–62
Journal: Journal of Neuroimmunology - Volume 210, Issues 1–2, 29 May 2009, Pages 52–62
نویسندگان
Saima Humayun, May Gohar, Kathryn Volkening, Katie Moisse, Cheryl Leystra-Lantz, Jennifer Mepham, Jesse McLean, Michael J. Strong,