کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3064826 | 1580454 | 2010 | 9 صفحه PDF | دانلود رایگان |
In this study we showed that in vivo bacterial lipopolysaccharide (LPS) challenge elevated IL-1β level in the rodent hippocampus. Antagonists of P2X receptors inhibited LPS-induced IL-1β level with a pharmacological profile similar to that of P2X7R and their inhibitory effect was attenuated in the absence of P2X7R. In wild-type mice, LPS overexpressed mRNA encoding P2X4 and P2X7 receptors in the hippocampus and caused also a remarkable increase in the levels of IL-1β in the serum. The hippocampal increase of IL-1β has substantially alleviated when contamination of circulating blood cells was excluded by transcardial perfusion, indicating the peripheral origin of hippocampal IL-1β elevation. These results point to the key role of the endogenous activation of peripheral P2X7R in the level of IL-1β in rodent hippocampus under systemic bacterial endotoxin challenge.
Journal: Journal of Neuroimmunology - Volume 219, Issues 1–2, 26 February 2010, Pages 38–46