کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064883 | 1580457 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 216, Issues 1–2, 30 November 2009, Pages 92–97
Journal: Journal of Neuroimmunology - Volume 216, Issues 1–2, 30 November 2009, Pages 92–97
نویسندگان
Angela R. Kamer, Ronald G. Craig, Elizabeth Pirraglia, Ananda P. Dasanayake, Robert G. Norman, Robert J. Boylan, Andrea Nehorayoff, Lidia Glodzik, Miroslaw Brys, Mony J. de Leon,