کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3064961 | 1580456 | 2009 | 5 صفحه PDF | دانلود رایگان |

Rabies encephalitis is a significant health hazard, particularly in Asia. To understand the role of immune mechanisms and cytokines in rabies encephalitis, we performed a retrospective and prospective study on the autopsy material. Representative histopathological sections were studied and subjected to immunostaining for rabies virus antigen, TNF-α and IL-1β. Immunohistochemistry for IL-1β and TNF-α revealed expression of these cytokines in 96% of cases in microglial cells, macrophages and lymphocytes with a strong positive correlation between IL-1β and TNF-α immunopositivity and degree of perivascular and parenchymal inflammation. In addition, expression of IL-1β and TNF-α also correlated positively with each other. However there was no direct correlation of viral antigen load with grading of cytokine expression. These findings indicate that IL-1β and TNF-α together may play an important role to coordinate the dramatic inflammatory response associated with the rabies-encephalopathy. They may serve as important targets for future therapy.
Journal: Journal of Neuroimmunology - Volume 217, Issues 1–2, 10 December 2009, Pages 85–89