کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065025 | 1580467 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of neurosphere proliferation by IFNγ but not IFNβ is coupled to neuronal differentiation
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of neurosphere proliferation by IFNγ but not IFNβ is coupled to neuronal differentiation Inhibition of neurosphere proliferation by IFNγ but not IFNβ is coupled to neuronal differentiation](/preview/png/3065025.png)
چکیده انگلیسی
Interferons are produced following neural damage as part of the inflammatory response and may thus affect neural stem cell function. We compared the effects of interferon-γ and interferon-β on the proliferation and differentiation of adult murine neural progenitors. Both interferons inhibited neurosphere proliferation due to cell cycle arrest in G1 but only interferon-γ induced neuronal differentiation. Both interferons induced differential phosphorylation of STAT proteins and a modest and late upregulation of the cell cycle regulator p27 but not several other likely cell cycle regulators. Thus in neural progenitor cells, anti-proliferative effects of interferons are not necessarily linked to differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 206, Issues 1–2, 3 January 2009, Pages 32–38
Journal: Journal of Neuroimmunology - Volume 206, Issues 1–2, 3 January 2009, Pages 32–38
نویسندگان
M. Lum, E. Croze, C. Wagner, S. McLenachan, B. Mitrovic, A.M. Turnley,