کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065079 | 1580461 | 2009 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice Imatinib mesylate ameliorates the dystrophic phenotype in exercised mdx mice](/preview/png/3065079.png)
Myofiber degeneration, inflammation, and fibrosis are remarkable features of Duchenne muscular dystrophy. We hypothesized that the administration of imatinib mesylate, an inhibitor of tyrosine kinase and TGF-β pro-fibrogenic activity, could improve the muscular conditions in mdx mice. Four-week old mdx mice were treated and exercised for 6 weeks. Gastrocnemius and diaphragm histopathology, strength, creatine kinase, and cytokine levels were evaluated. The treated group presented increased muscular strength and decreased CK levels, injured myofibers, and inflammatory infiltrates. Pro-inflammatory cytokines and TGF-β were also reduced, while IL-10 was increased, suggesting an immunomodulatory effect of imatinib, which can ameliorate the dystrophic phenotype in mdx mice.
Journal: Journal of Neuroimmunology - Volume 212, Issues 1–2, 25 July 2009, Pages 93–101