کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065192 | 1580465 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time-dependent effects of striatal interleukin-2 on open field behaviour in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
There is evidence that immune messengers like cytokines can modulate emotional and motivated behaviours and are involved in psychiatric conditions like anxiety, and depression. Previously, we showed that cytokine gene expression (interleukin (IL)-2 mRNA) in specific brain tissues (striatum, prefrontal cortex) correlated with anxiety-like behaviour (open arm time) in an elevated plus-maze in rats. In a subsequent experiment, a single striatal IL-2 injection showed behavioural trends with the lower dose (1Â ng) acting in a behavioural suppressive way, whereas the highest dosage (25Â ng) led to activation and anxiolytic-like behaviour. Here, to support and extend our previous findings, we tested Wistar outbred rats after a single unilateral (balanced brain sites) IL-2 injection into the ventral/dorsal striatum followed by an open field test acutely and 24Â h later. Analyses for horizontal locomotion showed no differences between groups. However, rats with IL-2-treatment (0.1Â ng) showed a dose-dependent avoidance effect (i.e. reduced centre time) compared to the 1Â ng group and vehicle controls 24Â h later. In addition, suppression of free rearing activity was shown for both IL-2 doses (0.1; 1Â ng) compared to saline in the acute test, and partly 24Â h later. Thus, in experiment 2, we tested for proactive drug mechanisms to test for delayed effects of IL-2 as observed in experiment 1. In a new sample, rats were returned to their home cages after a striatal IL-2 injection (0.1; 0.01; 0Â ng), and tested 24Â h and 48Â h after the injection in an open field. Neither for the first (24Â h) nor for the second exposure (48Â h later) did the analyses show any significant behavioural effects. We therefore suggest that emotional-related behaviour can be modulated by striatal IL-2 for at least 24Â h. However, such IL-2 effects can only be observed if a mild stressful environmental challenge (i.e., forced open field exposure) is followed immediately after injection. In conclusion, proactive drug effects may be excluded for striatal IL-2 effects on open field behaviour.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 208, Issues 1â2, 31 March 2009, Pages 10-18
Journal: Journal of Neuroimmunology - Volume 208, Issues 1â2, 31 March 2009, Pages 10-18
نویسندگان
Britta D. Karrenbauer, Ying-Jui Ho, Verena Ludwig, Jeanette Löhn, Rainer Spanagel, Rainer K.W. Schwarting, Cornelius R. Pawlak,