کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065311 1580478 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models
چکیده انگلیسی

We compared the effects of peripheral Freund's Complete Adjuvant (CFA) and formalin injection on spinal microglia activation. Both qualitative and quantitative analyses showed signs of microglia activation on the ipsilateral side of the lumbar dorsal horn on day 3, day 7 and day 14 after formalin injection. However, significant microglia morphological alteration was not found in the CFA model. At the injection site in the paw, CFA injection induced considerably more inflammation than formalin injection. Although spinal microglia might be activated in inflammatory pain models, morphologically, spinal microglia activation was not closely correlated with peripheral inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 192, Issues 1–2, December 2007, Pages 40–48
نویسندگان
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