کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065323 1580478 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CSF proteomic fingerprints for HIV-associated cognitive impairment
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CSF proteomic fingerprints for HIV-associated cognitive impairment
چکیده انگلیسی

Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 192, Issues 1–2, December 2007, Pages 157–170
نویسندگان
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