کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065353 1580476 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model
چکیده انگلیسی

Inflammatory cytokines have been implicated in the pathology of multiple neurologic diseases, including multiple sclerosis. We examined the role of the TNF family member TWEAK in neuroinflammation. Cuprizone-fed mice undergo neuroinflammation and demyelination in the brain, but upon removal of cuprizone from the diet, inflammation is resolved and remyelination occurs. Using this model, we demonstrate that mice lacking TWEAK exhibit a significant delay in demyelination and microglial infiltration. During remyelination, mice lacking the TWEAK gene demonstrate only a marginal delay in remyelination. Thus, this study identifies a primary role of TWEAK in promoting neuroinflammation and exacerbating demyelination during cuprizone-induced damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 194, Issues 1–2, February 2008, Pages 97–106
نویسندگان
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