کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065360 | 1580476 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Natalizumab, the most recently approved treatment for relapsing multiple sclerosis (MS) exerts its action through binding to α4 integrins. We studied longitudinally gene expression profiles in peripheral blood of MS patients, treated with natalizumab for more than 2 years. The majority of altered genes relates to immune response, signal transduction, adhesion and metabolism. Not only gene expression relevant for T lymphocytes was altered, but also genes regulating B-lymphocyte, neutrophil and erythrocyte functions. Understanding these different gene effects and their interrelationships will provide more insights into additional mechanisms of action of natalizumab and possibly allow better prediction of adverse events.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 194, Issues 1–2, February 2008, Pages 153–164
Journal: Journal of Neuroimmunology - Volume 194, Issues 1–2, February 2008, Pages 153–164
نویسندگان
Raija L.P. Lindberg, Lutz Achtnichts, Francine Hoffmann, Jens Kuhle, Ludwig Kappos,