کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065376 1580472 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro
چکیده انگلیسی

Several matrix metalloproteinase (MMP) members contribute to pathology in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). As the role of MMP-12 in EAE has been understudied, we examined its expression in EAE and in vitro. MMP-12 transcripts increased with EAE, and protein was localized to a subset of macrophages/microglia. The temporal expression of MMP-12 largely corresponded to that of cytokines, and we demonstrate that IL-1β and TNF-α promoted MMP-12 expression in cultured macrophages. We postulate that cytokine — MMP-12 interactions are important in the disease process of EAE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 199, Issues 1–2, 13 August 2008, Pages 24–34
نویسندگان
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