کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065493 1580481 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of VLA4 polymorphisms in multiple sclerosis: An association study
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The role of VLA4 polymorphisms in multiple sclerosis: An association study
چکیده انگلیسی

Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 189, Issues 1–2, September 2007, Pages 125–128
نویسندگان
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