کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065500 1580481 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogeneity of immunopathological features of AChR/MuSK autoantibody-negative myasthenia gravis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Heterogeneity of immunopathological features of AChR/MuSK autoantibody-negative myasthenia gravis
چکیده انگلیسی

We compared B cells and germinal centers in thymus from myasthenia gravis (MG) patients either with anti-acetylcholine receptor (AChR) autoantibodies or with neither anti-muscle-specific tyrosine kinase (MuSK) nor anti-AChR (seronegative MG: SN-MG). The numbers and frequencies of total and germinal center B cells varied in the SN-MG thymi, some of which were normal/atrophic. Others were clearly hyperplastic, their B cell parameters overlapping with those in AChR-positive MG, which implicates the thymus in pathogenesis. Indeed, some SN-MG patients apparently benefited from thymectomy, which should be considered a management option.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 189, Issues 1–2, September 2007, Pages 163–168
نویسندگان
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