کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065550 | 1580482 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The involvement of regulatory T cells (Treg) in autoimmune-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to protein-misfolding and are accompanied by neuroinflammation. Since, it has been hypothesized that the neuroinflammation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant immune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4+Foxp3+) increases with age and is accompanied by intensified suppressive activity for Treg in patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 188, Issues 1–2, August 2007, Pages 117–127
Journal: Journal of Neuroimmunology - Volume 188, Issues 1–2, August 2007, Pages 117–127
نویسندگان
Daniela Rosenkranz, Sascha Weyer, Eva Tolosa, Alexandra Gaenslen, Daniela Berg, Thomas Leyhe, Thomas Gasser, Lars Stoltze,